J. Amer. Chem. Vol 81, p6085, 1959
 
 

APIC Clossaries-Melatonin, http://www.apicusa.com/melatonin.glos.html
 
 

Czeisler CA et al. N Engl J Med. 1995;332: 6-11. Moore RY. N Engl  J Med. 1995;332: 54-44
 
 

Dollins AB, Wurtman R et al. Proc Natl Acad Sci. 1994;91: 1824-1828
 
 
 

The melatonin craze, Geoffrey Cowley, Newsweek, August 1995.
 
 

L. Wetterberg, J. Neural Trans, suppl.13,290,1978
 
 
 
 

Collin 1971, Dodt 1973, Oksche 1984
 
 
 
 

Fluka Chemical Price List Index 1997/98
 
 
 
 

www.DirectResponse.com
 
 
 

BNN = Beilstein Registery Number (for Beilstein search with the Beilstein data base)
 
 
 
 

EC number corresponds with the  EINECS (European Inventory of Existing Commercial Chemical Substances ) or ELINCS (European List of Notified Chemical Substances) numbers.
 
 
 
 

The following prices of melatonin are taken from Sigma Biochemicals and Reagents For Life Science Research 1999 Index.
 www.sigma-aldrish.com
 
 
 
 

Tryptophan has a chiral centre at the carbon connected to the carboxylic acid and the amine groups. Hence, it has 2 optical isomers namely D-and L-tryptophan. The chemical names are [(R)-2-Amino-3-(3-indolyl)propionic acid] and [(S)-2-Amino-3-(3-indolyl)propionic acid] respectively.
 
 
 
 

Lapin, V.1976. Pineal gland and malignancy. Oster.Z. Onkol. 3, 51.
 
 

Sano, K, 1976. Diagnosis and treatment of tumours in the pineal region. Acta Neurochir. 34, 153.
 
 
 

Neuwelt, E.A., Glasberg, M., Frankel, E. and Clark, W.K. 1979. malignant pineal region tumours. J.Neurosurg. 51, 597.
 
 
 

Is there a role for the pineal gland in neoplastic growth?, M.Karasek, F. Fraschini, "Role of melatonin and pineal peptides in neuroimmunomodulation" edited by F. Fraschini, R.J. Reiter, Plenum Press, New York, 1991.
 
 

Pawlikowski and Karasek, 1990
 
 
 
 

Axelrod et al., 1965 ; Klein and Weller, 1970.
 
 
 
 

A.B. Lerner, J. D. Case and R.V.Heinzelman, Structure of melatonin, J. Amer. Chem Soc., Vol 18, 6085, 1959
 
 
 

V.Erspamer, J.Physiol., Vol 127, 118, 1955.
 
 
 

K.M. Biswas, A.H. Jackson, M.M. kobaisy and P.V.R. Shannon, Electrophilic substitution in indole and cyclisation of N-acyltryptamines, J.Chem. Soc. Persin Trans. 1, 461,1992.
 
 
 

M. Somei, K.Yamada, M. Hasegawa, M. Tabata, Y. Nagahama, H. Morikawa and  F. Yamada, Preparations of 1-hydroxyindole derivatives and their potent inhibitory activities on platelet aggreagation, Heterocycle, Vol. 43, No. 9, 1855, 1996.
 
 
 

B.W. Wilson, The Application of Mass Spectrometry to the Study of the Pineal Gland, J. Neural Trans., Suppl.13, 279, 1978.
 
 
 

J.Arendt, Melatonin Assays in Body Fluids, J.Neural Trans., Suppl 13, 265, 1978. 



M.E. Flaugh, T.A.Crowell, J.A. Clemens, and B. D. Sawyer, Synthesis and evaluation of  the antiovulatory activity of a variety of  melatonin analoques, J. Med. Chem., Vol.22, No.1 : 63-69, 1979.



J. Szmuzkovicz, W.C. Anthony, and R.V. Heinzelman, Synthesis of N-acetyl-5-methoxytryptamine, J.Org. Chem, Vol 25, 857-859, 1960.



G. Falkenberg and D. Carlstrom, Acta Cryst., B27, 411,1971.



I.L. Karle, K.S. Dragonette, and S.A. Brenner, Acta Cryst., 19, 713, 1965.