Synthesis of heterocycle-annelated naphthyridones with a bridgehead nitrogen atom

Reaction conditions and yields

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Compound		Base -	Reaction time/h	Yield (%)
No.	Structure
6		KOBut	1.5	82
7		KOBut	3	64
8		KOBut K2CO3	2 2	85 47
9		KOBut K2CO3 DBU	1.5 3 3	87 47 54
10		KOBut K2CO3	2 3	51 58
11		KOBut K2CO3	2 2	78 63
12		K2CO3	2	86
14		K2CO3	2	44
15		K2CO3	2	37
16		KOBut K2CO3 DBU	2 3 2	88 75 58
17		K2CO3	2	64
19		K2CO3 Cs2CO3	4 3	52 55