We found that thiyl radical addition-cyclization of the hydroximates smoothly proceeded to give the cyclized products. The newly found radical cyclization provides a synthetically useful method for the construction of butyrolactones widely found in biologically active natural products.
1) Introduction [click here for details]
2) Thiyl Radical Addition-Cyclization of the Z-Hydroximates [click here for details]
3) Conversion of the Cyclic Hydroximates to the Lactones [click here for details]
4) Synthesis of Oxo-parabenzlactone [click here for details]
5) Conclusion [click here for details]
6) Acknowledgments and References [click here for details]