Table 1. Stability Constants for 1 with neutral substrate added K (M-1)a

Neutral guest

Stability constant (M-1)

methanol

12.7 ± 1.0

ethanol

10.7 ± 0.7

benzyl alcohol

9.7 ± 0.7

isopropyl alcohol

7.0 ± 0.4

sec-butanol

6.2 ± 0.4

N-formylglycine ethyl ester

13.3 ± 1.0

N,N-dimethylformamide

11.3 ± 0.8

N,N-dimethylacetamide

9.0 ± 0.9

1,1,3,3-tetramethylurea

2.2 ± 0.1

dimethyl sulfoxide

16.2 ± 1.1

1,2-dimethylimidazole

5.4 ± 0.3

acetone

2.2 ± 0.2

nitromethaneb

-

a In benzene-d6 at 298 K. For each titration, the concentration of 1 was held constant (at ca. 4 x 10-3 M) as aliquots of the substrate in benzene-d6 (ca. 1 M) were added. b In this instance, the induced shifts in the NH proton(s) of 1 were too small (< 0.15 ppm) to afford a reliable Ka value.

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