Email Discussion: Keynote paper 4 - Stan Roberts et al METH-COHN Otto
Email Discussion: Re: Keynote Paper 4:(fao METH-COHN Otto) Nick Turner

Contents

• Introduction
• Hydrolases
  • enzyme-catalysed hydrolyses of carboxylic acid esters and amides, phosphate esters, nitriles and epoxides;
  • esterification and inter-esterification reactions catalysed by enzymes;
• Oxidoreductases
  • reduction of ketones to secondary alcohols using whole-cell systems or isolated dehydrogenases;
  • oxidation of alicyclic and aromatic substrates using mono-oxygenases and di-oxygenases in bacteria and fungi including enzyme-catalysed Baeyer-Villiger oxidations;
• Carbon-carbon bond forming reactions
  • aldol reactions;
  • formation of optically active cyanohydrins and enzyme-catalysed acyloin type reactions.
• Future Developments of Biotransformations
  • The use of these biocatalytic methods for the stereocontrolled preparation of important target structures is reviewed and some of the future directions for the biotransformation area are discussed.