Aldol Type Reactions of the Pyrrolidinone
Generation of the silyl enol ether (10) has allowed a
variety of aldol type-reactions to be performed:
Fluoride ion mediated aldol reactions.4
Line broadening occurs in the 1H NMR due to amide resonance, but
high temperature NMR has improved the resolution of the peaks.
Dehydration of the beta-hydroxy ketones to the enone has been achieved.
Lewis Acid Mediated aldol reactions