Address:


Dr. Josette Michon
LEDSS Université Joseph Fourier
BP 53
F38041 Grenoble Cedex 9
Tel : 33 76 51 44 30
Fax : 33 76 51 43 82

Fields of Interest:



     Molecular recognition: EPR studies using
nitroxide probes

  1. Interaction of mono- and bi- nitroxide radicals with cyclodextrins.
  2. Interaction with DNA of an endonuclease labelled with a nitroxide
radical.


     Study of potentially anticancer drugs by EPR:
spin-trapping experiments.


Selected references:



"Generation and identification of the amidyl radical resulting from homolytic N-O
cleavage in carcinogenic N-acetyl-N-(acyloxy)-2-aminofluorene" 
J. Org. Chem., 1993, 6143-6145

"Electron spin resonance study of the complexation of long -(polyethylene glycol) chain
biradicals by gamma-cyclodextrins - Alkaline salts-induced changes"
New J. Chem., 1992, 915-918.

"Selective oxidation of beta-cyclodextrin by photochemical reaction with p-
nitroacetophenone"
Tet. Lett., 1992, 3315-3318.

"Kinetics of reduction of a nitroxide radical by ascorbic acid in the presence of beta-
cyclodextrin. Determination of the radical/beta-cyclodextrin association constant and rate
constants for reaction of the free and complexed nitroxide radical" 
New J. Chem., 1988, 125-128.


Key-words:

DNA
EPR - spin labelling - spin trapping
Molecular recognition