Generic/Code Name
Fluconazole

Other Name
Diflucan

CAS Name
1H-1,2,4-Triazole-1-ethanol, alpha-(2,4-difluorophenyl)-alpha-(1H-1,2,4-triazol-1-ylmethyl)-3

CAS Number
86386-73-44

Dosage Form
Tablets (50, 100, and 200 mg); powder for oral suspension (35ml bottles containing 10 or 40 mg/ml when reconstituted); intravenous solutions (100ml and 200ml volumes containing 2 mg/ml, packaged in glass or Viaflex containers)27

Stability and Storage
Store tablets and powder for oral suspension below 30 C (86 F). Store reconstituted oral suspension between 5-30 C (41-86 F); protect from freezing. Store injection in glass bottles between 5-30 C (41-86 F). Store injection in Viaflex containers between 5-25 C (41-77 F). Brief exposure up to 40 C (104 F) does not adversely affect the product. Protect injection from freezing.

Physical Description
White crystalline solid

Solubility
Slightly soluble in water (8mg/ml at 37 C) and soluble in alcohol (25mg/ml at 20 C)

Melting Point
138-140 C36

Elemental Composition
C50.98%, H3.95%, F12.41%, N27.44%, O5.22%37

Other Uses
Fluconazole is FDA-approved for the treatment of vaginal, oropharyngeal, and esophageal candidiasis, as well as serious systemic infections (peritonitis, pneumonia, and urinary tract infections) caused by Candida species. It also is approved for prevention of candidiasis in patients undergoing bone marrow transplant who receive cytotoxic chemotherapy or radiation therapy. Non-approved indications include treatment of onychomycosis caused by Trichophyton and Candida species and treatment of tinea corporis, cruris, pedis, and manuum.

Manufacturers
Fluconazole
Pfizer Inc, 235 East 42nd Street New York, NY 10017-5755.
(800) 438-1985
 
Spectral information (click on image to enlarge)

             FT -IR               IR assignments          Mass spec

        Proton NMR        Carbon NMR    Expanded ¹³C NMR   NMR assignments