Sibutramine - References

¹Carla A. Luque*, Jose A. Rey; The discovery and status of sibutramine as an anti-obesity drug; European Journal of Pharmacology 440; 2002; 119-128

²Buckett, W.R., Hopcroft, R.H., Luscombe, G.P., Thomas, P.C.; 1987a; BTS 54524, a monoamine uptake inhibitor exhibiting potent actions in models predictive of potential antidepressant activity; Br. J. Pharmacol. 90, 94P.

³Buckett, W.R., Luscombe, G.P., Thomas, P.C.; 1987b; The putative antidepressant BTS 54524 rapidly and potently down-regulates cortical hadrenoceptors in the rat; Br. J. Pharmacol. 90, 261P.

⁴Buckett, W.R., Thomas, P.C., Luscombe, G.P.; 1988; The pharmacology of sibutramine hydrochloride (BTS 54524), a new antidepressant which induces rapid noradrenergic down-regulation; Prog. Neuro-Psychopharmacol. Biol. Psychiatry 12, 575-584.

⁵King, D.J., DeVaney, N.; 1988; Clinical pharmacology of sibutramine hydrochloride (BTS 54524), a new antidepressant, in healthy volunteers; Br. J. Clin. Pharmacol. 26, 607- 611.

⁶Kelly, F., Jones, S.P., Lee, I.K.; 1995; Sibutramine weight loss in depressed patients; Int. J. Obes. 19, 145.

⁷Kiyoharu Ukai et al; US Patent no. 4,939,175; July 3, 1990

⁸Jerussi, et al; US Patent no. 6,476,078; November 5, 2002

⁹Mendel et al; US Patent no. 6,346,549; February 12, 2002 (Addictive disorders)

¹⁰Mendel et al; US Patent no. 6,403,650; June 11, 2002 (Pulmonary hypertension)

11Mendel et al; US Patent no. 6,433,020; August 13, 2002 (Cardiovascular disease)

¹²Mendel et al; US Patent no. 6,376,551; April 23, 2002 (Chronic Fatigue Syndrome)

¹³Mendel et al; US Patent no. 6,372,798; April 16, 2002 (Hyperactivity disorders)

¹⁴Mendel et al; US Patent no. 6,372,797; April 16, 2002 (Menstrual dysfunction)

¹⁵Mendel et al; US Patent no. 6,365,632; April 2, 2002 (Orthostatic hypotension)

¹⁶Beilstein online database. http://www.beilstein.com

¹⁷Fang, Qun K.; Senanayake, Chris H.; Han, Zhengxu et al; Tetrahedron: Asymmetry; EN; 10; 23; 1999; 4477 - 4480.

¹⁸Jeffery, James E.; Kerrigan, Frank; Miller, Thomas K.; Smith, Graham J.; Tometzki, Gerald B.; J.Chem.Soc.Perkin Trans.1; EN; 21; 1996; 2583-2590.

¹⁹http://www.meridia.net

²⁰The Cambridge Crystal Structure Database

²¹http://www.yahoo.com (including Yahoo! health)

²²The American Obesity Association

²³www.FindArticles.com - Shawna Vogel; Why We Get Fat - Research on Genetics;Discover;April, 1999

²⁴Seagle, H.M., Bessesen, D.H., Hill, J.O.; 1998; Effects of sibutramine on resting metabolic rate and weight loss in overweight women; Obes. Res. 6; 115–121.

²⁵National Heart, Lung and Blood Institute treatment recommendations

²⁶NHS guide on the use of Sibutramine

²⁷Virginia's rat page

²⁸Medline Plus

²⁹Abbott Laboratories - guidance for the use of Meridia

³⁰www.ehendrick.com for information on Pulmonary hypertension.

³¹www.irishheart.ie for information on Cardiovascular disease.

³²web.ukonline.co.uk for information on Chronic Fatigue Syndrome.

³³www.ihdi.uky.edu for information on Hyperactivity disorders.

³⁴www.clevelandclinicmeded.com for information on Menstrual dysfunction.

³⁵www.ehendrick.org for information on Orthostatic hypotension.

³⁶cebmh.warne.ox.ac.uk for information on anticholinergic drugs.