In this site you will find information on the discovery, synthesis, biological action, side effects and physical data concerning the molecule Viagra® (Sildenafil Citrate)
Introduction: Viagra®, or sildenafil citrate as it is known technically, must be one of the most infamous drugs to have been released in the least few years. Newspapers are full of articles on Viagra related deaths, as well as those on the justification of free availability of the drug on the NHS(UK). And indeed the internet is full of sites offering Viagra for sale without prescription
Whatever your view, there are many interesting things associated with Viagra . The discovery of Viagra is an interesting one, as it was an accident, the researchers were not even investigating erectile dysfunction (ED). The biological mechanism of the drug illustrates a classic example of the use of mechanistic understanding to develop a drug. This involved the use of the knowledge of first and second messenger system to design and synthesise an appropriate drug. The function of Viagra as a treatment for erctile dysfunction(ED) has sparked an interest in compounds , which claim to perform a similar function. However, Viagras clinical trials do indeed confirm its effectiveness, which cannot be confirmed for other spin-offs on the market.
The names Viagra, sildenafil and sildenafil citrate are used interchangeably throughout this Websites. The citrate part of Viagra is not important for its biological function.
By Simon Llewellyn 1999
Structural information