phys

PHYSICAL PROPERTIES of melatonin and related compounds

	Common name : Melatonin Chemical names : N-acetyl-5-methoxytrptamine N-[2-(5-methoxy-1H-indol-3-yl)ethyl] 3-(N-Acetyl-2-aminoethyl)-5-methoxy indole N-[2-(5-Methoxy-1H-indol-3-yl] Empirical formula : C₁₃H₁₆N₂O₂ Molecular mass : 232.28 amu Melting point : 116~118 ^oC Possible harzard : No possible harzard has been reported Normal state : Crystalline solid Density: 1.29 g/cc Colour : Pale yellow Prices : Laboratory analytical proposes : £ 29.10 (1 g) £ 7.90 (100 mg) £ 12.00 (250 mg) £ 32.00 (1 g) Melatonin tablet retail prices : £ 20.00 (100 x 300 mcg) BNN : 205542 EC no. : 2007977
	Common name : Tryptophan Chemical names : [2-Amino-3-(3-indolyl)propionic acid] Isomerism : Tryptophan molecule has a chiral centre at the carbon connected to the carboxylic acid and the amine groups. Hence, it has 2 optical isomers namely D- and L-tryptophan or [(R)-2-Amino-3-(3-indolyl)propionic acid] and [(S)-2-Amino-3-(3-indolyl)propionic acid] respectively. L-tryptophan is the amino acid precursor of serotonin and melatonin. Empirical formula : C₁₁H₁₂N₂O₂ Molecular mass : 204.3 amu Melting point : 295^oC Solubility : Complete, colourless (0.1M in 0.5 M HCl, 20 ^oC) Prices : L-tryptophan Laboratory analytical proposes : £ 15.30 (5 g) D-tryptophan Laboratory analytical proposes : £ 5.50 (1 g) D,L-tryptophan Laboratory analytical proposes : £ 11.40 (25 g) £ 35.60 (100g) BNN : 86197 (L-tryptophan) 86198 (R-tryptophan) EC no. : 2007956 (L-tryptophan) 2058199 (R-tryptophan)
	Common name : 5-Hydroxytryptophan Chemical names : 2-Amino -3-[5-hydroxyindolyl]-propionic acid Isomerism : 5-hydroxy tryptophan has a chiral centre at the carbon connected to the amine group. Hence, it has 2 optical isomers namely 5-hydroxy-L-tryptophan and 5-hydroxy-D-tryptophan respectively.The D form is an inactive isomer. The L form is an immediate precursor of melatonin synthesis in tryptophan metabolic pathway, L-aromatic amino acid and decarboxylase substrate. Empirical formula : C₁₁H₁₂N₂O₃ Molecular mass : 220.2 amu Melting point : Possible harzard : Harmful by inhalation, in contact with skin or if swallowed. Safety phrase : Need to wear suitable protective clothing when handling. Price : 5-Hydroxy -L-tryptophan £5.00 (100 mg) 5-Hydroxy-D-tryptophan £27.20 (100 mg) 5-Hydroxy-DL-tryptophan £5.30 (100 mg)
	Common name : N-Acetylserotonin Chemical names : N-Acetyl-5-hydroxy tryptamine Empirical formula : C₁₂H₁₄N₂O₂ Molecular mass : 218.3 amu Price : £26.70 (100 mg)
	Common name : Serotonin Chemical names : 5-hydroxy-L-Tryptophan 5-hydroxytryptamine L-2-amino-3-[5-hydroxyindolyl]-propionic acid L-5-HTP Empirical formula : C₁₀H₁₂N₂O Molecular mass : 176.2 amu Melting point : Serotonin creatine sulfate monohydrate ( C₁₀H₁₂N₂O. C₄H₉N₃O₅S.H₂O ) m.p.= 220 ^oC Serotonin hydrochloride (C₁₀H₁₂N₂O.HCl) m.p.= 167-168 ^oC Serotonin hydrogen maleate (C₁₀H₁₂N₂O. C₄H₄0₄) m.p. = 154-158 ^oC Serotonin hydrogen oxalate (C₁₀H₁₂N₂O.C₂H₂0₄) m.p.= 195=200 ^oC Possible harzard : Harmful by inhalation, Harmful if in contact with skin, Harmful if swallowed.