All steroids have the same general tetracyclic ring structure, consisting
of three 6-membered rings (ABC) and one 5-membered ring (D) fused
together. The numbering system of the nucleus and sidechain remains
unchanged even when bridgehead methyl groups are removed.
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3D Representation
Naturally-occurring steroids have trans BC and - except
for the cardiac glycosides - CD ring junctions, where cis/trans
describes the relationship of the two acyclic bridgehead substituents.
AB Junctions (represented here in the Decalin models) can be
found either cis - as in Digitoxigenin or the bile acid
Deoxycholic Acid - or more commonly as trans. |