Recently, the 100th anniversary of the birth of the famous chemist Derek Barton was celebrated with a symposium. One of the many wonderful talks presented was by Tobias Ritter and entitled “Late-stage fluorination for PET imaging” and this resonated for me. The challenge is how to produce C-F bonds under mild conditions quickly so that 18F-labelled substrates can be injected for the PET imaging. Ritter has several recent articles on this theme which you should read.[cite]10.1021/ja2048072[/cite],[cite]10.1021/acs.accounts.7b00413[/cite].
Posts Tagged ‘Barton’
Concerted Nucleophilic Aromatic Substitution Mediated by the PhenoFluor Reagent.
Thursday, September 20th, 2018Tags:Antimatter, Barton, Chemistry, Derek Barton, Fluorine, Medical physics, Medicinal radiochemistry, Natural sciences, Neuroimaging, Physical sciences, Positron emission tomography, Radiation therapy, Ritter, Tobias Ritter
Posted in Interesting chemistry | 9 Comments »