Mini datument - p.1

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CAN (2.1eq) was added to a solution of the amine (1.0eq) in 5:1 MeCN:H2O and the solution stirred for two hours at room temperature. The reaction was quenched by addition of saturated aqueous sodium bicarbonate solution and partitioned between brine and Et2O, dried and concentrated in vacuo. The crude product was purified by column chromatography.

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Lithium N-benzyl-N-a-methyl-4-methoxybenzylamide may be employed as a homochiral ammonia equivalent for the synthesis of homochiral b-haloaryl-b-amino acid derivatives via a strategy involving its conjugate addition to a,b-unsaturated b-haloaryl acceptors and subsequent oxidative deprotection with ceric ammonium nitrate.