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Links to the Rest of the Paper:
1. Introduction
2. Model Studies: The Basic Schmidt Reaction,
wherein we study the regioselectivity of the rearrangement and the stereoselectivity
of the iminium ion reduction.
- A. Regioselectivity of the Schmidt Reaction: Assembly
of the Basic Core of Gephyrotoxin.
B. The Use of a Secondary Azide: Stereoselectivity
of the Iminium Ion Reduction.
3. Initial Efforts to Synthesize Gephyrotoxin,
wherein we struggle with the regioselectivity of the indene alkylation and the choice
of a synthetic equivalent for the 2-hydroxyethyl side chain.
- C. Alkylation of Methoxyindene and Schmidt Reactions
of Regioisomeric Azidoindenes
D. Regiocontrolled Routes to the Cyclization Precusors: Avoid
Indene Alkylations
4. Formal Synthesis of Gephyrotoxin, wherein
we finally get it right.
5. References (THIS PAGE)