Bibliography

 Web Resources and Database Searching

The whole of this project was created using the online resources discussed in the Chemical Information Technology (CIT) lectures. Pictures and images were obtained using the Google and Altavista search engines. Google was also useful for some chemical information. It did return a lot of hits, but most were only superficially related to the subject. More success was obtained with Web Of Science (WOS), Scifinder Scholar and Medline (OVID) databases. These gave many relevant results ; however, some were of a very advanced nature and were not included in the project. For quick relevant chemical information, such as physical properties, syntheses, and some spectra, Beilstein was unbeatable.

All of the 2D chemical structures and synthetic schemes were created using the ChemDraw program. The Cambridge Crystallographic Database and Brookhaven Protein Database provided the 3D structure of warfarin and enzyme structures respectively. Spectra were obtained from the NIST Chemistry WebBook, SDBS and Sigma-Aldrich.

Many of the databases used provided literature references only. The IC online library system proved to be an extremely simple yet very effective way of locating the actual publications (chemical and others), with direct links to most publishers. Most of the journals were online so that viewing and downloading them was quite straightforward.

All the resources and databases provided a huge amount of information. The main difficulty in making this project was deciding what to actually include. Since the project is based on a drug, medical and biochemical information are inevitable. However, an attempt has been made to keep medical jargon to a strict minimum, and clear definitions given where appropriate. I have attempted to include information which highlight the chemistry behind the drug. Finally, the design of the web pages has been kept simple to prevent distraction from the subject.

Web sources

www.coumadin.com
www.biochemist.org/bio/02401/0015/024010015.pdf
www.pathology.vcu.edu/news/clots3.pdf
www.sigma-aldrich.com
www.people.vcu.edu/~urdesai/cou.htm
www.ntri.tamuk.edu/homepage-ntri/lectures/clotting.html
www.neoucom.edu/DEPTS/BIOC/Fall%20Syllabus%202002-2003/08%20Blood%20Coagulation.pdf
www.heartcenteronline.com
http://daccx.bsd.uchicago.edu/drug/Bulletins/N0695.html
www.hipglobal.com/html/library/Deep_vein_thrombosis/deep_vein_thrombosis.htm
www.endovascularone.com/pulmonary_embolism.htm
www.bristolmyerssquibb.com
www.barrlabs.com
www.astrazeneca.com
www.taropharma.co.uk
http://webbook.nist.gov/chemistry/
http://oca.ebi.ac.uk/oca-bin/ocamain
www.aist.go.jp/RIODB/SDBS/menu-e.html
www.forbes.com/home/2002/12/09/cx_mh_1209azn.html

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