Some Properties of Tamoxifen.

Physical Properties.

• Molecular Formula : C₂₆H₂₉NO
• Molecular Weight : 371.52 g / mol
• Melting Point : 96-98 ^o C

Spectroscopic Property.

Proton ( H1 ) NMR Spectrum Signals.

d = Chemical Shift ( in ppm )

J = Coupling constant in Hertz ( Hz )

• d=0.90 ( Triplet , 3H's ,J=7Hz, CH₃CH₂)
• d=2.25 ( Singlet , 6H's, (CH₃)₂N )
• d=2.3-2.8 ( multiplet, 4H's CH₃CH₂= and NCH₂)
• d=3.90 ( Triplet 2H's, J=6Hz , OCH)
• d=6.50 ( Doublet , 2H's J=10Hz)
• d=6.75 (Doublet, 2H's, J=10Hz)
• d=7.15 (Singlet , 5H's Aromatic H's)
• d =7.30 (Singlet , 5H's Aromatic)

UV Reactivity.

Converts Trans isomer into the Cis isomer.

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