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Functional group transformation |
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Functional groups on the cubane system generally
behaves very well. Functional group transformation can be applied successfully.
For example, the preparation of 1,4-dinitrocubane from cubane-1,4-dicarboxylic
acid. (The mechanism is provided on the right hand side.) Classical methodology
is used here. |
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Substitution on the cubane framework is fairly
easy done by the cubyl radical. However, the problem is such that a mixture
of products are obtained. Thus, to achieve controlled substitution on the
cubane framework, we need to carefully study the chemistry of the cubane
system. |
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Now, let us proceed to the systematic substitution
on the cubane nucleus: |
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