1.   Conversion an epoxide to Fluconazole

This method involves the conversion of the epoxide into fluconazole which gives a good yield of arond 44%.  The epoxide was prepared from commercially available difluorobenzene which only took three apparently simple steps and and was convienient due to its one-pot method however this only results in a yield of about 4-8% of the epoxide.  While the ring opening of the epoxide is expected to take place at the least hindered end, it is not impossible for the tertiary carbon to be attacked and produce

1. Conversion an epoxide to Fluconazole  2.   Lithiated or grignard difluorobenzene to Fluconazole
3.   Laboratory suitable method    4.   Commercially viable method: Sulphate process